Copy number calling and SNV classification using targeted short read sequencing


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Documentation for package ‘PureCN’ version 1.13.1

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annotateTargets Annotate targets with gene symbols
bootstrapResults Bootstrapping variant fits
calculateBamCoverageByInterval Function to calculate coverage from BAM file
calculateGCContentByInterval Calculates GC content by interval
calculateIntervalWeights Calculate interval weights
calculateLogRatio Calculate coverage log-ratio of tumor vs. normal
calculateMappingBiasVcf Calculate Mapping Bias
calculatePowerDetectSomatic Power calculation for detecting somatic mutations
calculateTangentNormal Calculate tangent normal
callAlterations Calling of amplifications and deletions
callAlterationsFromSegmentation Calling of amplifications and deletions from segmentations
callLOH Get regions of LOH
callMutationBurden Call mutation burden
centromeres A list of data.frames containing centromere positions.
correctCoverageBias Correct for library-specific coverage biases
createCurationFile Create file to curate PureCN results
createNormalDatabase Create database of normal samples
createTargetWeights Calculate target weights
filterIntervals Remove low quality intervals
filterTargets Remove low quality targets
filterVcfBasic Basic VCF filter function
filterVcfMuTect Filter VCF MuTect
filterVcfMuTect2 Filter VCF MuTect2
findBestNormal Find best normal sample in database
findFocal Find focal amplifications
getSexFromCoverage Get sample sex from coverage
getSexFromVcf Get sample sex from a VCF file
plotAbs Plots for analyzing PureCN solutions
poolCoverage Pool coverage from multiple samples
predictSomatic Predict germline vs. somatic status
preprocessIntervals Preprocess intervals
processMultipleSamples Multi sample normalization and segmentation
PureCN-defunct Defunct functions in package 'PureCN'
PureCN-deprecated Deprecated functions in package 'PureCN'
purecn.DNAcopy.bdry DNAcopy boundary data
purecn.example.output Example output
readCoverageFile Read coverage file
readCurationFile Read curation file
runAbsoluteCN Run PureCN implementation of ABSOLUTE
segmentationCBS CBS segmentation
segmentationHclust Minimal segmentation function
segmentationPSCBS PSCBS segmentation
setMappingBiasVcf Set Mapping Bias VCF
setPriorVcf Set Somatic Prior VCF